In the context of substance abuse, what does the term 'tolerance' refer to?

In the context of substance abuse, the term 'tolerance' specifically refers to the phenomenon where an individual requires larger amounts of a substance to achieve the same psychoactive effect that they previously experienced with smaller doses. This occurs as the body adapts to the presence of the substance, leading to diminished sensitivity over time.

As a person continues to use the substance, their neurobiological systems adjust, and the original quantity no longer produces the desired effects, prompting them to consume more in order to feel the same outcomes. This increase in dosage can exacerbate the problems associated with substance use, including further physical or psychological dependence.

Understanding tolerance is crucial for health professionals working with individuals who misuse substances, as it can impact treatment strategies and inform discussions about risk factors that lead to escalation in use.