What is a significant risk associated with opioid use?

Overdose is a significant risk associated with opioid use because opioids can significantly depress the central nervous system. When taken in high doses or combined with other depressants like alcohol, the respiratory system can slow down to dangerous levels or even stop, leading to respiratory failure, coma, or death. This risk is heightened with the increasing prevalence of potent synthetic opioids, such as fentanyl, which can be lethal even in small amounts.

In contrast, the other options do not reflect common or serious risks associated with opioid use. Weight gain may occur in some individuals but is not a direct consequence of opioid use. Increased energy levels and enhanced cognitive function are generally contrary to the effects of opioids, which tend to cause sedation and drowsiness rather than increased alertness or activity.